MDL 72832 hydrochloride

Name: MDL 72832 hydrochloride
Brand: tocris
SKU: 0412

Catalog # 0412

Datasheet / COA / SDS

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Bio-Techne Corporation

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$35 to United States

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Key Product Details

Description:	Potent 5-HT_1A ligand
Chemical Name:	8-[4-(1,4-Benzodioxan-2-ylmethylamino)butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	422.95

View Full Technical Details for MDL 72832 hydrochloride

Biological Activity

A potent ligand at 5-HT_1A receptors, with mixed agonist and antagonist properties. An agonist at post-synaptic 5-HT_1A receptors.

Technical Data

M. Wt	422.95
Formula	C₂₂H₃₀N₂O₄.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	113777-40-5
PubChem ID	45073438
InChi Key	GQGDGISNRPBRSG-UHFFFAOYSA-N
Smiles	Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		5

Preparing Stock Solutions

The following data is based on the product molecular weight 422.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	47.29 mL	236.43 mL	472.87 mL
0.25 mM	9.46 mL	47.29 mL	94.57 mL
0.5 mM	4.73 mL	23.64 mL	47.29 mL
2.5 mM	0.95 mL	4.73 mL	9.46 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Millan Induction of hypothermia as a model of 5-hydroxytryptamine_1A receptor-mediated activity in the rat - a pharmacological characterization of the actions of novel agonists and antagonists. J.Pharmacol.Exp.Ther. 1993 PMID: 8450471
Mir MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT_1A receptors. Eur.J.Pharmacol. 1988 PMID: 2840295