MAP4

Tocris Bioscience a Bio-Techne Brand

Catalog # 0711

Citations (1)

COA / SDS

Discontinued Product

0711 has been discontinued. View all Group II mGluR Agonists products.

Key Product Details

Description:	Potent group II mGlu agonist; also group III mGlu antagonist
Chemical Name:	(S)-2-Amino-2-methyl-4-phosphonobutanoic acid
Purity:	≥96% (HPLC)
Molecular Weight:	197.13

View Full Technical Details for MAP4

Biological Activity for MAP4

MAP4 is a selective group III metabotropic glutamate receptor antagonist in some electrophysiological systems. Group II/group III agonist in certain neurochemical systems.

Technical Data for MAP4

M. Wt	197.13
Formula	C₅H₁₂NO₅P
Storage	Store at RT
Purity	≥96% (HPLC)
CAS Number	157381-42-5
PubChem ID	1795545
InChi Key	HONKEGXLWUDTCF-YFKPBYRVSA-N
Smiles	N[C@](CCP(O)(O)=O)(C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MAP4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.71	100

Preparing Stock Solutions for MAP4

The following data is based on the product molecular weight 197.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.07 mL	25.36 mL	50.73 mL
5 mM	1.01 mL	5.07 mL	10.15 mL
10 mM	0.51 mL	2.54 mL	5.07 mL
50 mM	0.10 mL	0.51 mL	1.01 mL

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Reconstitution Calculator

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References for MAP4

References are publications that support the biological activity of the product.

Kemp Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. Eur.J.Pharmacol. 1996 PMID: 8864697
Sekiyama Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 1996 PMID: 8730745
Salt and Eaton Distinct presynaptic metabotropic receptors for L-AP4 and CCGl on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo. Neuroscience 1995 PMID: 7753406
Jane Actions of two new sub-type selective metabotropic glutamate receptor antagonists in the neonatal rat spinal cord. Br.J.Pharmacol. 1994 PMID: 7921606

Citations for MAP4 (1)

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Citations are publications that use Bio-Techne products. Selected citations for MAP4 include:

Piet et al. (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. J Neurosci. 101:2151
PMID: 14766975

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Product Documents for MAP4

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.