M62812

Name: M62812
Brand: Tocris Bioscience
SKU: 5705
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5705

(1)

Citations (2)

COA / SDS

TLR-4 inhibitor

Discontinued Product

5705 has been discontinued. View all Toll-like Receptor Inhibitors products.

Key Product Details

Description:	TLR-4 inhibitor
Chemical Name:	6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	330.23

View Full Technical Details for M62812

Technical Data
Citations / Reviews (1)

Biological Activity for M62812

M62812 is a TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC₅₀ = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

Compound Libraries for M62812

M62812 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for M62812

M. Wt	330.23
Formula	C₁₃H₁₁N₃OS.2HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	613263-00-6
PubChem ID	44224214
InChi Key	SMTKPLISDFNJDJ-UHFFFAOYSA-N
Smiles	NC1=CC=CC=C1OC2=CC=C3C(SN=C3N)=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for M62812

References are publications that support the biological activity of the product.

Nakamura Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 2007 PMID: 17588563