m-Chlorophenylbiguanide hydrochloride

Name: m -Chlorophenylbiguanide hydrochloride
Brand: Tocris Bioscience
SKU: 0440

Catalog # 0440

Citations (4)

COA / SDS

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Key Product Details

Description:	Potent and selective 5-HT₃ agonist
Chemical Name:	1-(3-Chlorophenyl)biguanide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	248.11

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Biological Activity

m-Chlorophenylbiguanide hydrochloride is a prototypical potent and selective 5-HT₃ receptor agonist.

Technical Data

M. Wt	248.11
Formula	C₈H₁₀ClN₅.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	2113-05-5
PubChem ID	2730228
InChi Key	FOWAIJYHRWFTHR-UHFFFAOYSA-N
Smiles	Cl.NC(=N)NC(=N)NC1=CC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	24.81	100

Preparing Stock Solutions

The following data is based on the product molecular weight 248.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.03 mL	20.15 mL	40.30 mL
5 mM	0.81 mL	4.03 mL	8.06 mL
10 mM	0.40 mL	2.02 mL	4.03 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

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References

References are publications that support the biological activity of the product.

Niemeyer and Lummis Different efficacy of specific agonists at 5-HT₃ receptor splice variants: the role of the extra six amino acid segment. Br.J.Pharmacol. 1998 PMID: 9517385
Boess 5HT₃ receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide. Neuropharmacology 1992 PMID: 1407396
Sepulveda The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT₃ receptors in N1E-115 neuroblastoma cells. Br.J.Pharmacol. 1991 PMID: 1797317
Kilpatrick 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT₃ receptor agonist. Eur.J.Pharmacol. 1990 PMID: 2144822

Citations for <em>m</em>-Chlorophenylbiguanide hydrochloride (4)

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Citations are publications that use Bio-Techne products. Selected citations for m-Chlorophenylbiguanide hydrochloride include:

Dale et al. (2014) Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol. 28:891
PMID: 25122043
Schulz et al. (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol. 167:1480
PMID: 22817643
Huang et al. (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. PLoS One. 29:13909
PMID: 19890001
Gill et al. (2008) Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 295:G700
PMID: 18669621

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