m-Chlorophenylbiguanide hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0440
Potent and selective 5-HT3 agonist
Discontinued Product
0440 has been discontinued.
View all 5-HT3 Receptor Agonists products.
Key Product Details
Description
Potent and selective 5-HT3 agonist
Product Description
m-Chlorophenylbiguanide hydrochloride is a prototypical potent and selective 5-HT3 receptor agonist.Product Specifications
Molecular Weight
248.11
Formula
C8H10ClN5.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1-(3-Chlorophenyl)biguanide hydrochloride
CAS Number
2113-05-5
PubChem ID
2730228
InChI Key
FOWAIJYHRWFTHR-UHFFFAOYSA-N
SMILES
Cl.NC(=N)NC(=N)NC1=CC(Cl)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 24.81 | 100 |
Preparing Stock Solutions
for m-Chlorophenylbiguanide hydrochloride
The following data is based on the product molecular weight 248.11
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.03 mL | 20.15 mL | 40.30 mL |
| 5 mM | 0.81 mL | 4.03 mL | 8.06 mL |
| 10 mM | 0.40 mL | 2.02 mL | 4.03 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sepulveda The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br.J.Pharmacol. 1991 PMID: 1797317
- Kilpatrick 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT3 receptor agonist. Eur.J.Pharmacol. 1990 PMID: 2144822
- Niemeyer and Lummis Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. Br.J.Pharmacol. 1998 PMID: 9517385
- Boess 5HT3 receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide. Neuropharmacology 1992 PMID: 1407396
Product Specific Notices for m-Chlorophenylbiguanide hydrochloride
For research use only
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