Lys-CoA

Name: Lys-CoA
Brand: Tocris Bioscience
SKU: 5103

Tocris Bioscience, part of Bio-Techne | Catalog # 5103

COA / SDS

Selective p300 inhibitor

Discontinued Product

5103 has been discontinued. View all Histone Acetyltransferase Inhibitors products.

Key Product Details

Description:	Selective p300 inhibitor
Chemical Name:	S-[2-[[(5S)-5-(Acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl]coenzyme A trifluoroacetate
Purity:	≥95% (HPLC)
Molecular Weight:	1108.82

View Full Technical Details for Lys-CoA

Technical Data
Citations

Biological Activity for Lys-CoA

Lys-CoA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC₅₀= 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC₅₀ = 200 μM). Inhibits p300-dependent transcription. Active in vivo.

Technical Data for Lys-CoA

M. Wt	1108.82
Formula	C₃₁H₅₃N₁₀O₁₉P₃S.C₂HF₃O₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
Smiles	O[C@H]([C@@H]1OP(O)(O)=O)[C@@H](O[C@@H]1COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)N2C3=NC=NC(N)=C3N=C2.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Lys-CoA

References are publications that support the biological activity of the product.

Cebrat Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg.Med.Chem. 2003 PMID: 12837541
Liu The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 2008 PMID: 18273021
Burns Iso-coenzyme A. J.Biol.Chem. 2005 PMID: 15708855
Lau HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol.Cell. 2000 PMID: 10882143

Lys-CoA

Tocris Bioscience, part of Bio-Techne | Catalog # 5103

Key Product Details

Biological Activity for Lys-CoA

Technical Data for Lys-CoA

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Lys-CoA

Product Documents for Lys-CoA

COA

Certificate of Analysis

SDS

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