LY 2389575 hydrochloride

Name: LY 2389575 hydrochloride
Brand: Tocris Bioscience
SKU: 4969

Tocris Bioscience, part of Bio-Techne | Catalog # 4969

COA / SDS

Selective negative allosteric modulator of mGlu3 receptors

Discontinued Product

4969 has been discontinued. View all Group II mGluR Modulators products.

Key Product Details

Description:	Selective negative allosteric modulator of mGlu₃ receptors
Chemical Name:	(3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	438.58

View Full Technical Details for LY 2389575 hydrochloride

Technical Data
Citations

Biological Activity for LY 2389575 hydrochloride

LY 2389575 hydrochloride is a selective negative allosteric modulator of mGlu₃ (IC₅₀ = 190 nM). Exhibits > 65-fold selectivity for mGlu₃ over other mGlu receptors. Abolishes the neuroprotective action of LY 379268 against amyloid β toxicity in mixed cortical neuronal and astrocyte cell cultures.

Technical Data for LY 2389575 hydrochloride

M. Wt	438.58
Formula	C₁₅H₁₅BrCl₂N₄.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	885104-09-6
PubChem ID	11503054
InChi Key	IRIBLLOEUZMCQY-ZOWNYOTGSA-N
Smiles	ClC1=CC(Cl)=CC=C1CN[C@@H]2CN(C3=NC=C(Br)C=N3)CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LY 2389575 hydrochloride

References are publications that support the biological activity of the product.

Caraci Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGl Mol.Pharmacol. 2011 PMID: 21159998

LY 2389575 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4969

Key Product Details

Biological Activity for LY 2389575 hydrochloride

Technical Data for LY 2389575 hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for LY 2389575 hydrochloride

Product Documents for LY 2389575 hydrochloride

COA

Certificate of Analysis

SDS

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