LY 235959

Name: LY 235959
Brand: Tocris Bioscience
SKU: 1019

Catalog # 1019

Citations (2)

COA / SDS

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Key Product Details

Description:	Competitive NMDA antagonist
Chemical Name:	[3S-(3α,4aα,6β,8aα)]-Decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid)
Molecular Weight:	277.26

View Full Technical Details for LY 235959

Biological Activity

LY 235959 is a competitive NMDA receptor antagonist.

Licensing Information

Sold with the permission of Eli Lilly and Company.

Technical Data

M. Wt	277.26
Formula	C₁₁H₂₀NO₅P
Storage	Desiccate at +4°C
CAS Number	137433-06-8
PubChem ID	131938
InChi Key	STIRHCNEGQQBOY-QEYWKRMJSA-N
Smiles	[H][C@]12[C@](CC[C@H](CP(O)(O)=O)C2)([H])CN[C@H]([C@](O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 277.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.61 mL	18.03 mL	36.07 mL
5 mM	0.72 mL	3.61 mL	7.21 mL
10 mM	0.36 mL	1.80 mL	3.61 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Borowicz Competitive NMDA-receptor antagonists, LY 235959 and LY 233053, enhance the protective efficacy of various antiepileptic drugs against maximal electroshock-induced seizures in mice. Epilepsia 1996 PMID: 8681893
Ellison Competitive and non-competitive NMDA antagonists induce similar limbic degeneration. Neuroreport 1994 PMID: 7696633

Citations for LY 235959 (2)

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Citations are publications that use Bio-Techne products. Selected citations for LY 235959 include:

Fowler et al. (2011) Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Nature. 471:597
PMID: 21278726
Kenny et al. (2009) NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala. Neuropsychopharmacology. 34:266
PMID: 18418357

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