LY 2183240

Tocris Bioscience, part of Bio-Techne | Catalog # 2452

Highly potent anandamide uptake inhibitor; also inhibits FAAH
Discontinued Product
2452 has been discontinued. View all Cannabinoid Transporter Inhibitors products.

Key Product Details

Description

Highly potent anandamide uptake inhibitor; also inhibits FAAH

View all Cannabinoid Transporter Inhibitors »

Product Description

LY 2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.

Licensing Information

Sold under license from Eli Lilly and Company

Product Specifications

Molecular Weight

307.35

Formula

C17H17N5O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-[(1,1'-Biphenyl]-4-yl)methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide

CAS Number

874902-19-9

PubChem ID

11507802

InChI Key

GZNIYOXWFCDBBJ-UHFFFAOYSA-N

SMILES

CN(C)C(=O)N1N=NN=C1CC1=CC=C(C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.74 100
Ethanol 15.37 50 with gentle warming

Preparing Stock Solutions for LY 2183240

The following data is based on the product molecular weight 307.35

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for LY 2183240

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 2183240

For research use only

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