LDN 212854

Name: LDN 212854
Brand: Tocris Bioscience
SKU: 6151

Tocris Bioscience, part of Bio-Techne | Catalog # 6151

COA / SDS

Potent bone morphogenetic protein type I (ALK) inhibitor

Discontinued Product

6151 has been discontinued. View all ALK Inhibitors products.

Key Product Details

Description:	Potent bone morphogenetic protein type I (ALK) inhibitor
Chemical Name:	5-(6-(4-(1-Piperazinyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Purity:	≥98% (HPLC)
Molecular Weight:	406.48

View Full Technical Details for LDN 212854

Technical Data
Citations

Biological Activity for LDN 212854

LDN 212854 is a potent ALK inhibitor (IC₅₀ values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Exhibits selectivity for ALK2 over ALK4 and ALK5 in cellular assays. Inhibits heterotopic ossification in a mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. Also exhibits activity against RIPK2, ABL1 and PDGFR-β (IC₅₀ values < 100 nM).

Licensing Information

Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patent 14/776,302

Technical Data for LDN 212854

M. Wt	406.48
Formula	C₂₅H₂₂N₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1432597-26-6
PubChem ID	60182388
InChi Key	BBDGBGOVJPEFBT-UHFFFAOYSA-N
Smiles	N1(C2=CC=C(C3=CN4N=CC(C5=CC=CC6=C5C=CC=N6)=C4N=C3)C=C2)CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LDN 212854

References are publications that support the biological activity of the product.

Mohedas Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 2013 PMID: 23547776