LDC 000067

Name: LDC 000067
Brand: Tocris Bioscience
SKU: 6752

Tocris Bioscience, part of Bio-Techne | Catalog # 6752

COA / SDS

Potent and selective CDK9 inhibitor

Discontinued Product

6752 has been discontinued. View all Cyclin-dependent Kinase Inhibitors products.

Key Product Details

Description:	Potent and selective CDK9 inhibitor
Chemical Name:	3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	370.43

View Full Technical Details for LDC 000067

Technical Data
Citations

Biological Activity for LDC 000067

LDC 000067 is a potent and selective CDK9 inhibitor (IC₅₀ = 44 nM at CDK9-cyclin T1). Inhibits other CDKs in the micromolar range (IC₅₀ values are 2.4, 5.5, 9.2, >10 and >10 μM for CDK2-cyclin A, CDK1-cyclin B1, CDK4-cyclin D1, CDK6-cyclin D3 and CDK7-cyclin H-MAT1, respectively). Inhibits P-TEFb-dependent in vitro transcription. Induces apoptosis in vitro and in vivo in combination with BI 894999.

Technical Data for LDC 000067

M. Wt	370.43
Formula	C₁₈H₁₈N₄O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1073485-20-7
PubChem ID	25104564
InChi Key	GGQCIOOSELPMBB-UHFFFAOYSA-N
Smiles	COC1=C(C2=NC=NC(NC3=CC(CS(N)(=O)=O)=CC=C3)=C2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LDC 000067

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Gerlach The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML. Oncogene 2018 PMID: 29491412
Brägelmann Systematic kinase inhibitor profiling identifies CDK9 as a synthetic lethal target in NUT midline carcinoma. Cell Rep. 2017 PMID: 28930680
Albert Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor. Br.J.Pharmacol. 2014 PMID: 24102143

LDC 000067

Tocris Bioscience, part of Bio-Techne | Catalog # 6752

Key Product Details

Biological Activity for LDC 000067

Technical Data for LDC 000067

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for LDC 000067

Product Documents for LDC 000067

COA

Certificate of Analysis

SDS

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