L-NMMA acetate

Name: L-NMMA acetate
Brand: Tocris Bioscience
SKU: 0771
Price: 88 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0771

Citations (6)

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Key Product Details

Description:	Non-selective NOS inhibitor
Chemical Name:	NG-Monomethyl-L-arginine acetate
Molecular Weight:	248.28

View Full Technical Details for L-NMMA acetate

Biological Activity for L-NMMA acetate

L-NMMA acetate is a competitive, irreversible inhibitor of all three NOS isoforms.

Technical Data for L-NMMA acetate

M. Wt	248.28
Formula	C₇H₁₆N₄O₂.CH₃CO₂H
Storage	Desiccate at RT
CAS Number	53308-83-1
PubChem ID	135242
InChi Key	IKPNWIGTWUZCKM-JEDNCBNOSA-N
Smiles	CC(O)=O.N=C(NCCC[C@H](N)C(O)=O)NC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-NMMA acetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	12.41	50

Preparing Stock Solutions for L-NMMA acetate

The following data is based on the product molecular weight 248.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.06 mL	40.28 mL	80.55 mL
2.5 mM	1.61 mL	8.06 mL	16.11 mL
5 mM	0.81 mL	4.03 mL	8.06 mL
25 mM	0.16 mL	0.81 mL	1.61 mL

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Reconstitution Calculator

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References for L-NMMA acetate

References are publications that support the biological activity of the product.

Reif and McCreedy N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a differential pattern of inactivation toward the three nitric oxide synthases. Arch.Biochem.Biophys. 1995 PMID: 7540822
Olken Inactivation of macrophage nitric oxide synthase activity by N(G)-methyl-L-arginine. Biochem.Biophys.Res.Commun. 1991 PMID: 2049105
Rees Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br.J.Pharmacol. 1990 PMID: 1706208
Saksuma Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc.Natl.Acad.Sci.U.S.A. 1988 PMID: 3263652

Citations for L-NMMA acetate (6)

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Citations are publications that use Bio-Techne products. Selected citations for L-NMMA acetate include:

Queval et al. (2016) STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. Sci Rep. 6:29297
PMID: 27384401
Schophuizen et al. (2015) Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. J Neurosci. 4:234
PMID: 26132391
Echeverría et al. (2014) Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One. 9:e94146
PMID: 24710004
Carlile et al. (2012) An anxiolytic-like effect of hyperbaric oxygen in the mouse light/dark exploration test. Life Sci. 90:267
PMID: 22154905
Yang (2007) Modulation of inhibitory activity by nitric oxide in the thalamus. J Neurophysiol. 97:3386
PMID: 17376843
Kurata et al. (2004) beta-OE, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-MthD.-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms. J Pharmacol Exp Ther. 311:237
PMID: 15175425

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