L-NIL hydrochloride

Name: L-NIL hydrochloride
Brand: Tocris Bioscience
SKU: 1139
Price: 172 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 1139

Citations (4)

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Key Product Details

Description:	Selective iNOS inhibitor
Chemical Name:	N⁶-(1-Iminoethyl)-L-lysine hydrochloride
Molecular Weight:	223.7

View Full Technical Details for L-NIL hydrochloride

Biological Activity for L-NIL hydrochloride

L-NIL hydrochloride is a selective inhibitor of inducible nitric oxide synthase (IC₅₀ = 3.3 μM).

Technical Data for L-NIL hydrochloride

M. Wt	223.7
Formula	C₈H₁₇N₃O₂.HCl
Storage	Desiccate at -20°C
CAS Number	150403-89-7
PubChem ID	9794509
InChi Key	HJYWSATZDBEAOS-FJXQXJEOSA-N
Smiles	N=C(NCCCC[C@@H](C(O)=O)N)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-NIL hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	22.37	100

Preparing Stock Solutions for L-NIL hydrochloride

The following data is based on the product molecular weight 223.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.47 mL	22.35 mL	44.70 mL
5 mM	0.89 mL	4.47 mL	8.94 mL
10 mM	0.45 mL	2.24 mL	4.47 mL
50 mM	0.09 mL	0.45 mL	0.89 mL

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References for L-NIL hydrochloride

References are publications that support the biological activity of the product.

Connor Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur.J.Pharmacol. 1995 PMID: 7537678
Moore L-N⁶-(1-Iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J.Med.Chem. 1994 PMID: 7525961

Citations for L-NIL hydrochloride (4)

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Citations are publications that use Bio-Techne products. Selected citations for L-NIL hydrochloride include:

Elks et al. (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog. 9:e1003789
PMID: 24367256
Hervera et al. (2011) Peripheral effects of mor. and expression of μ-opioid receptors in the dorsal root ganglia during neuropathic pain: nitric oxide signaling. Mol Pain. 7:25
PMID: 21486477
Hervera et al. (2010) The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice. J Pharmacol Exp Ther. 334:887
PMID: 20498253
Pais et al. (2008) Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway. Mar Drugs. 5:43
PMID: 18844999

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