L-DON

Name: L-DON
Brand: Tocris Bioscience
SKU: 6809

Tocris Bioscience, part of Bio-Techne | Catalog # 6809

COA / SDS

Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters

Discontinued Product

6809 has been discontinued. View all Glutaminase Inhibitors products.

Key Product Details

Description:	Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters
Chemical Name:	6-Diazo-5-oxo-L-norleucine
Molecular Weight:	171.15

View Full Technical Details for L-DON

Technical Data
Citations

Biological Activity for L-DON

L-DON is a glutaminase inhibitor (K_i = 6 μM). Also inhibits other glutamine-using enzymes, amino acid transporters and transglutaminases. Displays antitumor effects and reduces tumor weight in a range of mouse xenograft models.

Technical Data for L-DON

M. Wt	171.15
Formula	C₆H₉N₃O₃
Storage	Store at -20°C
CAS Number	157-03-9
PubChem ID	9087
InChi Key	YCWQAMGASJSUIP-YFKPBYRVSA-N
Smiles	N[C@H](C(O)=O)CCC(C=[N+]=[N-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for L-DON

References are publications that support the biological activity of the product.

Ovejera Efficacy of 6-diazo-5-oxo-L-norleucine and N-[N-γ-glutamyl-6-diazo-5-oxo-norleucinyl]-6-diazo-5-oxo-norleucine against experimental tumors in conventional and nude mice. Cancer Res. 1979 PMID: 572261
Lemberg We're not "DON" yet: optimal dosing and prodrug delivery of 6-diazo-5-oxo-L-norleucine. Mol.Cancer Ther. 2018 PMID: 30181331
Thomas Kinetic characterization of ebselen, chelerythrine and apomor. as glutaminase inhibitors. Biochem.Biophys.Res.Commun. 2013 PMID: 23850693

L-DON

Tocris Bioscience, part of Bio-Techne | Catalog # 6809

Key Product Details

Biological Activity for L-DON

Technical Data for L-DON

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for L-DON

Product Documents for L-DON

COA

Certificate of Analysis

SDS

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