KRCA 0008

Tocris Bioscience, part of Bio-Techne | Catalog # 5098

Potent Ack1 and ALK dual inhibitor; orally bioavailable
Discontinued Product
5098 has been discontinued. View all ALK Inhibitors products.

Key Product Details

Description

Potent Ack1 and ALK dual inhibitor; orally bioavailable

View all ALK Inhibitors »

Product Description

KRCA 0008 is a potent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12 nM respectively). Inhibits lung cancer H3122 cell proliferation (IC50 = 80 nM). Attenuates H3122 cell xenograft tumor growth in mice. Orally bioavailable.

Product Specifications

Molecular Weight

609.12

Formula

C30H37ClN8O4

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

1,1'-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bisethanone

CAS Number

1472795-20-2

PubChem ID

72547474

InChI Key

TXDIRJCYNAWBOS-UHFFFAOYSA-N

SMILES

ClC1=C(NC2=C(OC)C=C(N3CCN(C(C)=O)CC3)C=C2)N=C(NC4=CC=C(N5CCN(C(C)=O)CC5)C=C4OC)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 60.91 100
DMSO 60.91 100
Ethanol 60.91 100

Preparing Stock Solutions for KRCA 0008

The following data is based on the product molecular weight 609.12

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.21 mL 16.42 mL
5 mM 0.33 mL 1.64 mL 3.28 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for KRCA 0008

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for KRCA 0008

For research use only

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