KM 11060

Name: KM 11060
Brand: Tocris Bioscience
SKU: 3143

Tocris Bioscience a Bio-Techne Brand

Catalog # 3143

Citations (1)

COA / SDS

Discontinued Product

3143 has been discontinued. View all Other CFTR Compounds products.

Key Product Details

Description:	Corrects F508del-CFTR trafficking
Chemical Name:	7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
Purity:	≥98% (HPLC)
Molecular Weight:	422.33

View Full Technical Details for KM 11060

Biological Activity for KM 11060

KM 11060 is a corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.

Technical Data for KM 11060

M. Wt	422.33
Formula	C₁₉H₁₇Cl₂N₃O₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	774549-97-2
PubChem ID	1241327
InChi Key	GIEHIZKCIZLXLF-UHFFFAOYSA-N
Smiles	ClC(C=C4)=CC=C4S(N(CC3)CCN3C1=CC=NC2=C1C=CC(Cl)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KM 11060

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.23	100
	ethanol	4.22	10

Preparing Stock Solutions for KM 11060

The following data is based on the product molecular weight 422.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.84 mL	23.68 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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Reconstitution Calculator

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References for KM 11060

References are publications that support the biological activity of the product.

Robert Structural analog of silde. identified as a novel corrector of the F508del-CFTR trafficking defect. Mol.Pharmacol. 2008 PMID: 17975008

Citations for KM 11060 (1)

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Citations are publications that use Bio-Techne products. Selected citations for KM 11060 include:

Zhao et al. (2013) Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. J Neuroinflammation. 8:e82683
PMID: 24367540

There are no citations that match your criteria.