K-252c

Product Description

K-252c is an inhibitor of protein kinase C (IC₅₀ = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC₅₀ = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC₅₀ values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC₅₀ values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).

Solubility

Preparing Stock Solutions for K-252c

The following data is based on the product molecular weight 311.34

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	12.85 mL	64.24 mL	128.48 mL
1.25 mM	2.57 mL	12.85 mL	25.70 mL
2.5 mM	1.28 mL	6.42 mL	12.85 mL
12.5 mM	0.26 mL	1.28 mL	2.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zimmermann Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 2000 PMID: 11080540
• McGovern and Shoichet Kinase inhibitors: not just for kinases anymore. J.Med.Chem. 2003 PMID: 12672248
• Fabre Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg.Med.Chem. 1993 PMID: 8081852