JX 401

Name: JX 401
Brand: Tocris Bioscience
SKU: 2657

Tocris Bioscience, part of Bio-Techne | Catalog # 2657

COA / SDS

Potent, reversible p38α inhibitor

Discontinued Product

2657 has been discontinued. View all p38 Inhibitors products.

Key Product Details

Description:	Potent, reversible p38α inhibitor
Chemical Name:	1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
Purity:	≥98% (HPLC)
Molecular Weight:	355.49

View Full Technical Details for JX 401

Technical Data
Citations

Biological Activity for JX 401

JX 401 is a potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC₅₀ values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

Compound Libraries for JX 401

JX 401 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for JX 401

M. Wt	355.49
Formula	C₂₁H₂₅NO₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	349087-34-9
PubChem ID	1126109
InChi Key	OMGLGPKQUFSRNN-UHFFFAOYSA-N
Smiles	COC1=C(C=CC(SC)=C1)C(=O)N1CCC(CC2=CC=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for JX 401

References are publications that support the biological activity of the product.

Friedmann JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol.Pharmacol. 2006 PMID: 16847144