JW 642

Name: JW 642
Brand: Tocris Bioscience
SKU: 4906

Tocris Bioscience, part of Bio-Techne | Catalog # 4906

COA / SDS

MAGL inhibitor

Discontinued Product

4906 has been discontinued. View all Monoacylglycerol Lipase Inhibitors products.

Key Product Details

Description:	MAGL inhibitor
Chemical Name:	4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	462.39

View Full Technical Details for JW 642

Technical Data
Citations

Biological Activity for JW 642

JW 642 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC₅₀ = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amide hydrolase (IC₅₀ = 20.6 μM). Analog of JZL 195 (Cat. No. 4715).

Licensing Information

Sold under license from The Scripps Research Institute

Technical Data for JW 642

M. Wt	462.39
Formula	C₂₁H₂₀F₆N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1416133-89-5
PubChem ID	71656520
InChi Key	AVSCNEOUWSVZEY-UHFFFAOYSA-N
Smiles	O=C(OC(C(F)(F)F)C(F)(F)F)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for JW 642

References are publications that support the biological activity of the product.

Chang Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 2012 PMID: 22542104