Indirubin-3'-oxime

Name: Indirubin-3'-oxime
Brand: Tocris Bioscience
SKU: 1813

Tocris Bioscience, part of Bio-Techne | Catalog # 1813

Citations (5)

COA / SDS

GSK-3β inhibitor; also inhibits cdks and other protein kinases

Discontinued Product

1813 has been discontinued. View all GSK-3 Inhibitors products.

Key Product Details

Description:	GSK-3β inhibitor; also inhibits cdks and other protein kinases
Alternative Names:	Indirubin-3'-monoxime
Chemical Name:	3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Purity:	≥99% (HPLC)
Molecular Weight:	277.28

View Full Technical Details for Indirubin-3'-oxime

Technical Data
Citations

Biological Activity for Indirubin-3'-oxime

Indirubin-3'-oxime is a inhibitor of GSK-3β (IC₅₀ = 190 nM) and cyclin dependent kinases (cdks; IC₅₀ values are 0.05, 0.18 and 0.25-0.5 βM for cdk9, cdk1 and cdk2, respectively). Also reported to inhibit AMPK, LCK and SGK. Inhibits cdk5- and GSK-3β-mediated tau phosphorylation. Induces cell cycle arrest and inhibits cell proliferation.

Technical Data for Indirubin-3'-oxime

M. Wt	277.28
Formula	C₁₆H₁₁N₃O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	160807-49-8
PubChem ID	5326739
InChi Key	LDEWQRSYYHTQRA-UHFFFAOYSA-N
Smiles	O\N=C1C2=CC=CC=C2NC/1=C1\C(=O)NC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Indirubin-3'-oxime

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Hoessel Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat.Cell.Biol. 1999 PMID: 10559866
Leclerc Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. J.Biol.Chem. 2001 PMID: 11013232
Bain The specificities of protein kinase inhibitors: an update. Biochem.J. 2003 PMID: 12534346

Indirubin-3'-oxime

Tocris Bioscience, part of Bio-Techne | Catalog # 1813

Key Product Details

Biological Activity for Indirubin-3'-oxime

Technical Data for Indirubin-3'-oxime

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Indirubin-3'-oxime

Product Documents for Indirubin-3'-oxime

COA

Certificate of Analysis

SDS

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