Immethridine dihydrobromide

Name: Immethridine dihydrobromide
Brand: Tocris Bioscience
SKU: 2315
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 2315

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Key Product Details

Description:	Potent H₃ agonist, highly selective over H₄
Chemical Name:	4-(1H-Imidazol-4-ylmethyl)pyridine dihydrobromide
Purity:	≥99% (HPLC)
Molecular Weight:	321.01

View Full Technical Details for Immethridine dihydrobromide

Biological Activity for Immethridine dihydrobromide

Immethridine dihydrobromide is a potent and highly selective histamine H₃ receptor agonist (pEC₅₀ = 9.74) that displays 300-fold selectivity over the H₄ receptor (pK_i values are 9.07 and 6.61 respectively). Does not bind to H₁ or H₂ receptors at concentrations up to 10 μM..

Technical Data for Immethridine dihydrobromide

M. Wt	321.01
Formula	C₉H₉N₃.2HBr
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	699020-93-4
PubChem ID	16759172
InChi Key	CYNKWHIKNDIVDR-UHFFFAOYSA-N
Smiles	Br.Br.C(C1=CN=CN1)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Immethridine dihydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	32.1	100

Preparing Stock Solutions for Immethridine dihydrobromide

The following data is based on the product molecular weight 321.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.58 mL	31.15 mL
5 mM	0.62 mL	3.12 mL	6.23 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for Immethridine dihydrobromide

References are publications that support the biological activity of the product.

Kitbunnadaj Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H₃ receptor agonist. J.Med.Chem. 2004 PMID: 15115383

Citations for Immethridine dihydrobromide

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H3 receptor targetting study was conducted by various targeting molecules such as Immethridine dihydrobromide

Name: Anonymous

Species: Human

H3 receptor targetting study was conducted by various targeting molecules such as Immethridine dihydrobromide. How H3 receptor targeting may help in autoimmune was the aim for the study. Excellent product.Ideal results obtained.

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Product Documents for Immethridine dihydrobromide

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.