Iloprost

Name: Iloprost
Brand: Tocris Bioscience
SKU: 2038

Tocris Bioscience, part of Bio-Techne | Catalog # 2038

Citations (12)

COA / SDS

Prostacyclin (PGI2) analog

Discontinued Product

2038 has been discontinued. View all Prostanoid Receptor Agonists products.

Key Product Details

Description:	Prostacyclin (PGI₂) analog
Alternative Names:	ZK 36374
Chemical Name:	(5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoic acid
Purity:	≥97% (HPLC)
Molecular Weight:	360.49

View Full Technical Details for Iloprost

Technical Data
Citations

Biological Activity for Iloprost

Iloprost is a prostacyclin (PGI₂) analog that binds with high affinity to IP, EP₁ and EP₃ receptors (K_i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP₁, EP₃, EP₄, FP, DP, EP₂ and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC₅₀ values are 0.24, 0.71 and 1.07 nM respectively).

Technical Data for Iloprost

M. Wt	360.49
Formula	C₂₂H₃₂O₄
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	78919-13-8
PubChem ID	5311181
InChi Key	HIFJCPQKFCZDDL-ACWOEMLNSA-N
Smiles	O[C@@H]1C[C@H]2[C@H](C/C(C2)=C/CCCC(O)=O)[C@H]1/C=C/[C@@H](O)C(C)CC#CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Iloprost

References are publications that support the biological activity of the product.

Abramovitz The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 2000 PMID: 10634944
Schror The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI₂ in vitro. Naunyn-Schmied.Arch.Pharmacol.
Della Bella Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 2001 PMID: 11403500

Iloprost

Tocris Bioscience, part of Bio-Techne | Catalog # 2038

Key Product Details

Biological Activity for Iloprost

Technical Data for Iloprost

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Iloprost

Product Documents for Iloprost

COA

Certificate of Analysis

SDS

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