Iloprost

Name: Iloprost
Brand: Tocris Bioscience
SKU: 2038

Catalog # 2038 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Prostacyclin (PGI2) analog

Discontinued Product

2038 has been discontinued. View all Prostanoid Receptor Agonists products.

Key Product Details

Description:	Prostacyclin (PGI₂) analog
Alternative Names:	ZK 36374
Chemical Name:	(5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoic acid
Purity:	≥97% (HPLC)
Molecular Weight:	360.49

View Full Technical Details for Iloprost

Technical Data
Citations (2) / Reviews

Biological Activity for Iloprost

Iloprost is a prostacyclin (PGI₂) analog that binds with high affinity to IP, EP₁ and EP₃ receptors (K_i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP₁, EP₃, EP₄, FP, DP, EP₂ and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC₅₀ values are 0.24, 0.71 and 1.07 nM respectively).

Technical Data for Iloprost

M. Wt	360.49
Formula	C₂₂H₃₂O₄
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	78919-13-8
PubChem ID	5311181
InChi Key	HIFJCPQKFCZDDL-ACWOEMLNSA-N
Smiles	O[C@@H]1C[C@H]2[C@H](C/C(C2)=C/CCCC(O)=O)[C@H]1/C=C/[C@@H](O)C(C)CC#CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Iloprost

References are publications that support the biological activity of the product.

Della Bella Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 2001 PMID: 11403500
Abramovitz The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 2000 PMID: 10634944
Schror The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI₂ in vitro. Naunyn-Schmied.Arch.Pharmacol.

Citations for Iloprost (2)

Showing 1 - 2 of 2 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Iloprost include:

Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. Nat Commun. 11:e1004118
PMID: 25723389
Flamm et al. (2012) Multiscale prediction of patient-specific platelet function under flow. Blood. 120:190
PMID: 22517902

There are no citations that match your criteria.