Idazoxan hydrochloride

Name: Idazoxan hydrochloride
Brand: Tocris Bioscience
SKU: 0793

Catalog # 0793

Citations (2)

COA / SDS

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Key Product Details

Description:	α₂ antagonist. Also I₂ ligand
Alternative Names:	RX 781094
Chemical Name:	2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride
Purity:	≥98%
Molecular Weight:	240.69

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Biological Activity

Idazoxan hydrochloride is a α₂-adrenoceptor antagonist, and I₂ ligand, selective over I₁ sites (pK_i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I₁, I₂, α_2A, α_2B, and α_2C receptors respectively).

Technical Data

M. Wt	240.69
Formula	C₁₁H₁₂N₂O₂.HCl
Storage	Store at RT
Purity	≥98%
CAS Number	79944-56-2
PubChem ID	154494
InChi Key	MYUBYOVCLMEAOH-UHFFFAOYSA-N
Smiles	Cl.C1CN=C(N1)C1COC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	24.07	100

Preparing Stock Solutions

The following data is based on the product molecular weight 240.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.15 mL	20.77 mL	41.55 mL
5 mM	0.83 mL	4.15 mL	8.31 mL
10 mM	0.42 mL	2.08 mL	4.15 mL
50 mM	0.08 mL	0.42 mL	0.83 mL

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References

References are publications that support the biological activity of the product.

Eglen 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 1998 PMID: 9786027
Berdeu Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur.J.Pharmacol. 1995 PMID: 7774667
Michel and Ernsberger Keeping an eye on the I site: imidazoline-preferring receptors. TIPS 1992 PMID: 1413085
Dabir Idazoxan: a novel pharmacological tool for the study of α₂-adrenoceptors. J.Pharmacol. 1986 PMID: 2875218

Citations for Idazoxan hydrochloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for Idazoxan hydrochloride include:

Sadeghi et al. (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapen. in rat single locus coeruleus neurons. Development. 172:460
PMID: 24372103
Bucher et al. (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab. 34:1128
PMID: 24714037

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