IC 261

Name: IC 261
Brand: Tocris Bioscience
SKU: 6676

Tocris Bioscience, part of Bio-Techne | Catalog # 6676

COA / SDS

CK1 inhibitor; displays selectivity for CK1δ and CK1ε

Discontinued Product

6676 has been discontinued. View all Casein Kinase 1 Inhibitors products.

Key Product Details

Description:	CK1 inhibitor; displays selectivity for CK1δ and CK1ε
Chemical Name:	1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	311.33

View Full Technical Details for IC 261

Technical Data
Citations

Biological Activity for IC 261

IC 261 is an ATP-competitive casein kinase 1 (CK1) inhibitor. Displays >15 fold selectivity for CK1δ and CK1ε over CK1α (IC₅₀ values are approximately 1 μM for CK1δ and CK1ε and 16 μM for CK1α). Arrests cell cycle at postmitotic G₁ phase in cells expressing p53. Inhibits CK1 mediated phosphorylation of LRRK2 in cell lines.

Technical Data for IC 261

M. Wt	311.33
Formula	C₁₈H₁₇NO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	186611-52-9
PubChem ID	3674
InChi Key	JBJYTZXCZDNOJW-UHFFFAOYSA-N
Smiles	COC1=CC(OC)=C(C(OC)=C1)/C=C2C(NC3=C/2C=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for IC 261

References are publications that support the biological activity of the product.

Mashhoon Crystal structure of a conformation-selective casein kinase-1 inhibitor. J.Med.Chem. 2000 PMID: 10749871
Chia Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat.Commun. 2014 PMID: 25500533
Behrend IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene 2000 PMID: 11103931

IC 261

Tocris Bioscience, part of Bio-Techne | Catalog # 6676

Key Product Details

Biological Activity for IC 261

Technical Data for IC 261

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for IC 261

Product Documents for IC 261

COA

Certificate of Analysis

SDS

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