I-CBP 112
Tocris Bioscience, part of Bio-Techne | Catalog # 4891
Selective CBP/p300 BRD inhibitor
Discontinued Product
4891 has been discontinued.
View all Bromodomain Inhibitors products.
Product Description
I-CBP 112 is a CBP/p300 bromodomain inhibitor (IC50 values are 0.142-0.17 and 0.625 μM for CBP and p300 respectively). Selective for CBP and p300 over ATAD2, BAZ2B, BRD2(2), BRD4(1), PB1(5), PCAF, PHIP(2) and TIF1α bromodomains in a BLI assay. Accelerates FRAP recovery in cells at a concentration of 1 μM.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the I-CBP 112 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of I-CBP 112 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
468.59
Formula
C27H36N2O5
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one
CAS Number
1640282-31-0
PubChem ID
90488984
InChI Key
YKNAKDFZAWQEEO-IBGZPJMESA-N
SMILES
COC(C(OC)=C1)=CC=C1C2=CC(OC[C@H]3CCCN(C)C3)=C(OCCN(C(CC)=O)C4)C4=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 100 | ||
| DMSO | 100 |
Preparing Stock Solutions
for I-CBP 112
The following data is based on the product molecular weight 468.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.67 mL | 21.34 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gallenkamp Bromodomains and their pharmacological inhibitors. ChemMedChem 2014 PMID: 24497428
Product Specific Notices for I-CBP 112
For research use only
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