Hispidulin

Name: Hispidulin
Brand: Tocris Bioscience
SKU: 2174

Tocris Bioscience a Bio-Techne Brand

Catalog # 2174

COA / SDS

Discontinued Product

2174 has been discontinued. View all GABA-A Receptor Benzodiazepines products.

Key Product Details

Description:	Partial positive allosteric modulator at the benzodiazepine site
Alternative Names:	Dinatin
Chemical Name:	5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	300.27

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Biological Activity for Hispidulin

Hispidulin is a partial positive allosteric modulator at the benzodiazepine receptor (IC₅₀ = 1.3 μM for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α1-, α2-, α3-, α5- or α6-β2 γ2S GABA_A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.

Technical Data for Hispidulin

M. Wt	300.27
Formula	C₁₆H₁₂O₆
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	1447-88-7
PubChem ID	5281628
InChi Key	IHFBPDAQLQOCBX-UHFFFAOYSA-N
Smiles	OC1=CC2=C(C(C=C(C3=CC=C(O)C=C3)O2)=O)C(O)=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Hispidulin

References are publications that support the biological activity of the product.

Kavvadias The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. Br.J.Pharmacol. 2004 PMID: 15231642
Kavvadias Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med. 2003 PMID: 12624814
Bourdillat Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. Eur.J.Pharmacol. 1988 PMID: 2836213

Citations for Hispidulin

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Hispidulin

Tocris Bioscience a Bio-Techne Brand

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Biological Activity for Hispidulin

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References for Hispidulin

Citations for Hispidulin

Product Documents for Hispidulin

COA

Certificate of Analysis

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