Hexamethonium bromide

Name: Hexamethonium bromide
Brand: Tocris Bioscience
SKU: 4111
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4111

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Key Product Details

Description:	Non-competitive nAChR antagonist
Chemical Name:	N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide
Molecular Weight:	362.19

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Biological Activity for Hexamethonium bromide

Hexamethonium bromide is a nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.

Technical Data for Hexamethonium bromide

M. Wt	362.19
Formula	C₁₂H₃₀Br₂N₂
Storage	Desiccate at RT
CAS Number	55-97-0
PubChem ID	5938
InChi Key	FAPSXSAPXXJTOU-UHFFFAOYSA-L
Smiles	C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Hexamethonium bromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	36.22	100
	DMSO	18.11	50

Preparing Stock Solutions for Hexamethonium bromide

The following data is based on the product molecular weight 362.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.80 mL	27.61 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for Hexamethonium bromide

References are publications that support the biological activity of the product.

Dasgupta Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc.Natl.Acad.Sci.
Karavaev The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro. Neurosci.Behav.Physiol. 2008 PMID: 18264777

Citations for Hexamethonium bromide

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Nicotinic blocker for decreasing stimulated dopamine release

Name: Anonymous

Species: Mouse

Assay Type: Ex Vivo

This is a fantastic drug for examining nicotinic receptor effects. It is easy to work with for slice recordings and washes out nicely. We typically use 50-200uM concentrations.

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