GYY 4137 morpholine salt

Name: GYY 4137 morpholine salt
Brand: Tocris Bioscience
SKU: 3658

Catalog # 3658 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Slow-releasing H2S donor

Key Product Details

Description:	Slow-releasing H₂S donor
Chemical Name:	P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt
Molecular Weight:	376.47

View Full Technical Details for GYY 4137 morpholine salt

Technical Data
Citations (1) / Reviews

Biological Activity for GYY 4137 morpholine salt

GYY 4137 morpholine salt is a slow-releasing H₂S donor. Exhibits vasodilator and antihypertensive activity. Activity causes slow dilation of blood vessels in vitro and in vivo; does not influence vascular smooth muscle cell viability in culture. Water-soluble.

Technical Data for GYY 4137 morpholine salt

M. Wt	376.47
Formula	C₁₁H₁₆NO₂PS₂.C₄H₉NO
Storage	Store at -20°C
CAS Number	106740-09-4
PubChem ID	46937261
InChi Key	YZMHNNLDUWRZFW-UHFFFAOYSA-N
Smiles	S=P(N1CCOCC1)(C2=CC=C(OC)C=C2)S.N3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GYY 4137 morpholine salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.65	100

Preparing Stock Solutions for GYY 4137 morpholine salt

The following data is based on the product molecular weight 376.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.28 mL	26.56 mL
5 mM	0.53 mL	2.66 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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Reconstitution Calculator

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References for GYY 4137 morpholine salt

References are publications that support the biological activity of the product.

Liu Hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E^-/- mice. Br.J.Pharmacol. [Epub ahead of print] 2013 PMID: 23713790
Lee The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One 2011 PMID: 21701688
Whiteman The effect of hydrogen sulfide donors on lipopolysaccaride-induced formation of inflammatory mediators in macrophages. Antioxid.Redox.Signal. 2010 PMID: 19769459
Li Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137). Circulation 2008 PMID: 18443240

Citations for GYY 4137 morpholine salt (1)

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Citations are publications that use Bio-Techne products. Selected citations for GYY 4137 morpholine salt include:

Y S et al. (2020) Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle. FASEB J. 34:12991-13004
PMID: 32777143

There are no citations that match your criteria.