GYY 4137 morpholine salt
Tocris Bioscience, part of Bio-Techne | Catalog # 3658
Slow-releasing H2S donor
Discontinued Product
3658 has been discontinued.
View all Miscellaneous Compounds products.
Product Description
GYY 4137 morpholine salt is a slow-releasing H2S donor. Exhibits vasodilator and antihypertensive activity. Activity causes slow dilation of blood vessels in vitro and in vivo; does not influence vascular smooth muscle cell viability in culture. Water-soluble.Product Specifications
Molecular Weight
376.47
Formula
C11H16NO2PS2.C4H9NO
Storage
Store at -20°C
Chemical Name
P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt
CAS Number
106740-09-4
PubChem ID
46937261
InChI Key
YZMHNNLDUWRZFW-UHFFFAOYSA-N
SMILES
S=P(N1CCOCC1)(C2=CC=C(OC)C=C2)S.N3CCOCC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.65 | 100 |
Preparing Stock Solutions
for GYY 4137 morpholine salt
The following data is based on the product molecular weight 376.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.66 mL | 13.28 mL | 26.56 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.31 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liu Hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E-/- mice. Br.J.Pharmacol. [Epub ahead of print] 2013 PMID: 23713790
- Whiteman The effect of hydrogen sulfide donors on lipopolysaccaride-induced formation of inflammatory mediators in macrophages. Antioxid.Redox.Signal. 2010 PMID: 19769459
- Lee The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One 2011 PMID: 21701688
- Li Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137). Circulation 2008 PMID: 18443240
Product Specific Notices for GYY 4137 morpholine salt
For research use only
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