GSK 5959
Tocris Bioscience, part of Bio-Techne | Catalog # 5385
Potent and selective BRPF1 inhibitor
Discontinued Product
5385 has been discontinued.
View all Bromodomain Inhibitors products.
Key Product Details
Description
Potent and selective BRPF1 inhibitor
Product Description
GSK 5959 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3. Cell permeable.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK 5959 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
394.47
Formula
C22H26N4O3
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
CAS Number
901245-65-6
PubChem ID
15990224
InChI Key
LTUGYAOMCKNTGG-UHFFFAOYSA-N
SMILES
CN(C1=CC(NC(C4=C(OC)C=CC=C4)=O)=C(N3CCCCC3)C=C1N2C)C2=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.94 | 10 with sonication |
Preparing Stock Solutions
for GSK 5959
The following data is based on the product molecular weight 394.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.35 mL | 126.75 mL | 253.50 mL |
| 0.5 mM | 5.07 mL | 25.35 mL | 50.70 mL |
| 1 mM | 2.54 mL | 12.68 mL | 25.35 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.07 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Demont 1,3-dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain. ACS Med.Chem.Lett. 2014 PMID: 25408830
Product Specific Notices for GSK 5959
For research use only
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