GSK 591 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5777
Potent and selective PRMT5 inhibitor
Discontinued Product
5777 has been discontinued.
View all Protein Arginine Methyltransferase Inhibitors products.
Key Product Details
Description
Potent and selective PRMT5 inhibitor
Alternative Names
EPZ015866,GSK 3203591
Product Description
GSK 591 dihydrochloride is a potent and selective PRMT5 inhibitor (IC50 = 4 nM). Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro.To request the negative control for GSK 591, please fill out the SGC 2096 request form on the SGC website.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK591 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK591 is reviewed on the Chemical Probes website.Product Specifications
Molecular Weight
453.41
Formula
C22H28N4O2.2HCl
Storage
Desiccate at RT
Purity
≥97% (HPLC)
Chemical Name
2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydropropyl]-4-pyridinecarboxamide dihydrochloride
CAS Number
2320953-89-5
PubChem ID
124201849
InChI Key
CDKUMVXFXBTOBE-FJSYBICCSA-N
SMILES
O[C@@H](CNC(C1=CC=NC(NC2CCC2)=C1)=O)CN3CC4=CC=CC=C4CC3.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 45.34 | 100 | |
| DMSO | 45.34 | 100 |
Preparing Stock Solutions
for GSK 591 dihydrochloride
The following data is based on the product molecular weight 453.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.03 mL | 22.06 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.41 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Scheer A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 2019 PMID: 30604761
- Duncan Structure and property guided design in the identification of PRMT5 tool compound EPZ015666. ACS.Med.Chem.Lett. 2015 PMID: 26985292
Product Specific Notices for GSK 591 dihydrochloride
For research use only
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