GSA 10

Name: GSA 10
Brand: Tocris Bioscience
SKU: 4918

Tocris Bioscience, part of Bio-Techne | Catalog # 4918

COA / SDS

Smo receptor agonist

Discontinued Product

4918 has been discontinued. View all Smoothened Receptor Agonists products.

Key Product Details

Description:	Smo receptor agonist
Chemical Name:	4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	450.53

View Full Technical Details for GSA 10

Technical Data
Citations

Biological Activity for GSA 10

GSA 10 is a smoothened (Smo) receptor agonist (EC₅₀ = 1.2 μM). Does not recognize the classic cyclopamine (Cat. No. 1623) binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Displays anti-adipogenic effects in vitro, mediated by a non-canonical Hedgehog signaling pathway. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Technical Data for GSA 10

M. Wt	450.53
Formula	C₂₆H₃₀N₂O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	300833-95-8
PubChem ID	54683103
InChi Key	MDLUYYGRCGDKGL-UHFFFAOYSA-N
Smiles	OC(C1=CC=CC=C1N2CCCCCC)=C(C(NC3=CC=C(C(OCCC)=O)C=C3)=O)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GSA 10

References are publications that support the biological activity of the product.

Fleury Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci.Rep. 2016 PMID: 27010359
Gorojankina Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol.Pharmacol. 2013 PMID: 23448715

GSA 10

Tocris Bioscience, part of Bio-Techne | Catalog # 4918

Key Product Details

Biological Activity for GSA 10

Technical Data for GSA 10

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for GSA 10

Product Documents for GSA 10

COA

Certificate of Analysis

SDS

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