GR 94800

Name: GR 94800
Brand: Tocris Bioscience
SKU: 1667

Tocris Bioscience, part of Bio-Techne | Catalog # 1667

COA / SDS

Potent, selective NK2 antagonist

Discontinued Product

1667 has been discontinued. View all NK2 Receptor Antagonists products.

Key Product Details

Description:	Potent, selective NK₂ antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	904.08

View Full Technical Details for GR 94800

Technical Data
Citations

Biological Activity for GR 94800

GR 94800 is a potent and selective tachykinin NK₂ receptor antagonist (pK_B values are 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors respectively). Active in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for GR 94800

M. Wt	904.08
Formula	C₄₉H₆₁N₉O₈
Single Letter Sequence	AAWFPPX (Modifications: Ala-1 = N-(Bz)Ala, Trp-3 = D-Trp, Pro-5 = D-Pro, X = Nle with C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	141636-65-9
PubChem ID	5487475
InChi Key	CWEISCOCKRHHOU-UJYVDGJVSA-N
Smiles	[H]N([C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCC)C(N)=O)C(=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GR 94800

References are publications that support the biological activity of the product.

McElroy Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J.Med.Chem. 1992 PMID: 1321907
Zagorodnyuk Evidence that tachykinin NK₁ and NK₂ receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum. Br.J.Pharmacol. 1995 PMID: 7545517
Matuszek An investigation of tachykinin NK₂ receptor subtypes in the rat. Eur.J.Pharmacol. 1998 PMID: 9718274