GR 46611

Name: GR 46611
Brand: tocris
SKU: 0864

Catalog # 0864

Citations (1)

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Key Product Details

Description:	5-HT_1D agonist
Chemical Name:	3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide
Molecular Weight:	377.49

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Biological Activity

5-HT_1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT_1D receptor ligands.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt	377.49
Formula	C₂₃H₂₇N₃O₂
Storage	Store at RT
CAS Number	185259-85-2
PubChem ID	6160690
InChi Key	LBVZWEWTNUDWNS-YRNVUSSQSA-N
Smiles	O=C(/C=C/C2=CC=C(NC=C3CCN(C)C)C3=C2)NCC1=CC=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	DMSO	50
	ethanol	10

Preparing Stock Solutions

The following data is based on the product molecular weight 377.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.30 mL	26.49 mL	52.98 mL
2.5 mM	1.06 mL	5.30 mL	10.60 mL
5 mM	0.53 mL	2.65 mL	5.30 mL
25 mM	0.11 mL	0.53 mL	1.06 mL

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References

References are publications that support the biological activity of the product.

Clitherow Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT_1D antagonists. J.Med.Chem. 1994 PMID: 8057272
Skingle Stimulation of central 5-HT_1D receptors causes hypothermia in the guinea pig. J.Psychopharmacol.

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for GR 46611 include:

Gu et al. (2007) Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury. J Urol. 177:2381
PMID: 17509363

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GR 46611

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References

Citations (1)

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