γDGG

Name: γ DGG
Brand: Tocris Bioscience
SKU: 0112
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0112

Citations (3)

(1)

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Key Product Details

Description:	Broad spectrum glutamatergic antagonist
Chemical Name:	γ-D-Glutamylglycine
Purity:	≥99% (HPLC)
Molecular Weight:	204.18

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Biological Activity for γDGG

γDGG is a broad spectrum glutamate receptor antagonist.

Technical Data for γDGG

M. Wt	204.18
Formula	C₇H₁₂N₂O₅
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	6729-55-1
PubChem ID	6604701
InChi Key	ACIJGUBIMXQCMF-SCSAIBSYSA-N
Smiles	N[C@@]([H])([C@](O)=O)CCC(NCC(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for γDGG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH		100
	water	20.42	100 with gentle warming

Preparing Stock Solutions for γDGG

The following data is based on the product molecular weight 204.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.90 mL	24.49 mL	48.98 mL
5 mM	0.98 mL	4.90 mL	9.80 mL
10 mM	0.49 mL	2.45 mL	4.90 mL
50 mM	0.10 mL	0.49 mL	0.98 mL

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References for γDGG

References are publications that support the biological activity of the product.

Aksenov Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classical conditioned eyeblinks and neuronal activity. J.Neurophysiol. 2005 PMID: 15331619
Jones Structure-activity relations of dipeptide antagonists of excitatory amino acids. Neuroscience 1984 PMID: 6392929

Citations for γDGG (3)

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Citations are publications that use Bio-Techne products. Selected citations for γDGG include:

Chen et al. (2013) The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci. 33:8336
PMID: 23658173
Young and Neher (2009) Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Neuron. 63:482
PMID: 19709630
Grueter et al. (2008) In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. J Neurosci. 28:9261
PMID: 18784306

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Customer Reviews for γDGG (1)

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gamma-DGG impact on whole-cell response of cerebellar neuron

Name: Anonymous

Species: Rat

Assay Type: Ex Vivo

Cell Line/Tissue: Cerebellum

Being added to perfusion solution at 0.5 mM concentration, gamma-DGG decreased electrical response amplitudes of pharmacologically isolated glutamate receptors in cerebellar neuron, and increased their paired-pulse ratio.

PMID: 23242311

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Product Documents for γDGG

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.