GBR 12935 dihydrochloride

Name: GBR 12935 dihydrochloride
Brand: Tocris Bioscience
SKU: 0514

Tocris Bioscience a Bio-Techne Brand

Catalog # 0514

COA / SDS

Discontinued Product

0514 has been discontinued. View all Dopamine Transporter Inhibitors products.

Key Product Details

Description:	Selective dopamine uptake inhibitor
Chemical Name:	1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Molecular Weight:	487.51

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Biological Activity for GBR 12935 dihydrochloride

GBR 12935 dihydrochloride is a potent and selective inhibitor of dopamine uptake (K_D = 5.5 nM in rat striatal membranes).

Technical Data for GBR 12935 dihydrochloride

M. Wt	487.51
Formula	C₂₈H₃₄N₂O.2HCl
Storage	Desiccate at -20°C
CAS Number	67469-81-2
PubChem ID	11957553
InChi Key	NQWRSILGEXNJIT-UHFFFAOYSA-N
Smiles	Cl.Cl.C(CN1CCN(CCOC(C2=CC=CC=C2)C2=CC=CC=C2)CC1)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GBR 12935 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.44	5

Preparing Stock Solutions for GBR 12935 dihydrochloride

The following data is based on the product molecular weight 487.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	41.02 mL	205.12 mL	410.25 mL
0.25 mM	8.20 mL	41.02 mL	82.05 mL
0.5 mM	4.10 mL	20.51 mL	41.02 mL
2.5 mM	0.82 mL	4.10 mL	8.20 mL

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References for GBR 12935 dihydrochloride

References are publications that support the biological activity of the product.

Reith GBR 12909 and 12935 block DA uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 1994 PMID: 8013544
Reith Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and DA to the DA transporter. Eur.J.Pharmacol. 1992 PMID: 1446712
Andersen Biochemical and pharmacological characterization of [³H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the DA uptake complex. J.Neurochem. 1987 PMID: 2952763

Citations for GBR 12935 dihydrochloride

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