GaTx2

Name: GaTx2
Brand: Tocris Bioscience
SKU: 4911

Tocris Bioscience, part of Bio-Techne | Catalog # 4911

Citations (48)

COA / SDS

High affinity, selective ClC-2 blocker; inhibits slow-gating

Discontinued Product

4911 has been discontinued. View all Other Chloride Channel Blockers products.

Key Product Details

Description:	High affinity, selective ClC-2 blocker; inhibits slow-gating
Alternative Names:	Leiuropeptide II
Molecular Weight:	3192.54

View Full Technical Details for GaTx2

Technical Data
Citations

Biological Activity for GaTx2

GaTx2 is a very high affinity ClC-2 blocker (apparent K_D ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABA_C, CaCC and K_V1.2.

Technical Data for GaTx2

M. Wt	3192.54
Formula	C₁₂₅H₁₉₉N₃₉O₄₇S₆
Single Letter Sequence	VSCEDCPDHCSTQKARAKCDNDKCVCEPI (Modifications: Disulfide bridge: 3-19, 6-24, 10-26)
Storage	Store at -20°C
CAS Number	194665-85-5
PubChem ID	90488986
InChi Key	NDCNPIYRYDSDEM-TZZHORBYSA-N
Smiles	[H]N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GaTx2

References are publications that support the biological activity of the product.

Thompson Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J.Biol.Chem. 2009 PMID: 19574231
Schiffhauer Dual activation of CFTR and CLCN2 by lubipro. in murine nasal epithelia. Am.J.Physiol.Lung Cell Mol.Physiol. 2013 PMID: 23316067

GaTx2

Tocris Bioscience, part of Bio-Techne | Catalog # 4911

Key Product Details

Biological Activity for GaTx2

Technical Data for GaTx2

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for GaTx2

Product Documents for GaTx2

COA

Certificate of Analysis

SDS

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