Galloflavin

Name: Galloflavin
Brand: Tocris Bioscience
SKU: 4795
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4795

(1)

Citations (14)

COA / SDS

Lactate dehydrogenase inhibitor; impairs aerobic glycolysis

Discontinued Product

4795 has been discontinued. View all Lactate Dehydrogenase A/LDHA Inhibitors products.

Key Product Details

Description:	Lactate dehydrogenase inhibitor; impairs aerobic glycolysis
Chemical Name:	3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione potassium salt
Purity:	≥95% (HPLC)
Molecular Weight:	316.26

View Full Technical Details for Galloflavin

Technical Data
Citations / Reviews (1)

Biological Activity for Galloflavin

Galloflavin is an inhibitor of human lactate dehydrogenase (LDH) (K_i values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate). Inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells; thought to decrease cell viability via impairment of aerobic glycolysis.

Technical Data for Galloflavin

M. Wt	316.26
Formula	C₁₂H₅O₈K
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1780260-20-9
PubChem ID	90488971
InChi Key	XSPGPNGPTLAWMC-UHFFFAOYSA-M
Smiles	[K+].OC1=C(O)C(O)=C2C3=C(OC(=O)C2=C1)C=C([O-])C(=O)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Galloflavin

References are publications that support the biological activity of the product.

Fiume Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells. Biochem.Biophys.Res.Commun. 2013 PMID: 23237800
Farabegoli Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur.J.Pharm.Sci. 2012 PMID: 22954722
Manerba Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem 2012 PMID: 22052811

Galloflavin

Tocris Bioscience, part of Bio-Techne | Catalog # 4795

Key Product Details

Biological Activity for Galloflavin

Technical Data for Galloflavin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Galloflavin

Product Documents for Galloflavin

COA

Certificate of Analysis

SDS

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