FX 1
Tocris Bioscience, part of Bio-Techne | Catalog # 6323
Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
Discontinued Product
6323 has been discontinued.
View all Bcl-2 Family Inhibitors products.
Key Product Details
Description
Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
Product Description
FX 1 is a Bcl-6 inhibitor (Kd = 3 μM); exhibits 10-fold greater potency than endogenous Bcl-6 corepressors. Disrupts formation of Bcl-6 repression complex. Induces regression of established tumors in mice bearing DLBCL xenograft.Product Specifications
Molecular Weight
368.82
Formula
C14H9ClN2O4S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid
CAS Number
1426138-42-2
PubChem ID
66488970
InChI Key
VISHSGZPGQKEFX-KHPPLWFESA-N
SMILES
OC(CCN1C(S/C(C1=O)=C2C(NC3=CC=C(C=C\23)Cl)=O)=S)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.88 | 100 |
Preparing Stock Solutions
for FX 1
The following data is based on the product molecular weight 368.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.71 mL | 13.56 mL | 27.11 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.42 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.71 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cardenas The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clin.Cancer Res. 2017 PMID: 27881582
- Cardenas Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. J.Clin.Invest. 2016 PMID: 27482887
Product Specific Notices for FX 1
For research use only
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