FR 139317

Name: FR 139317
Brand: Tocris Bioscience
SKU: 1210

Tocris Bioscience, part of Bio-Techne | Catalog # 1210

Citations (16)

COA / SDS

Highly potent, selective ETA antagonist

Discontinued Product

1210 has been discontinued. View all Endothelin ETA Receptor Antagonists products.

Key Product Details

Description:	Highly potent, selective ET_A antagonist
Chemical Name:	N-[N-[N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl]-1-methyl-D-tryptophyl]-3-(2-pyridinyl)-D-alanine
Purity:	≥99% (HPLC)
Molecular Weight:	604.75

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Technical Data
Citations

Biological Activity for FR 139317

FR 139317 is a highly potent and selective ET_A endothelin receptor antagonist (K_i values are 1 nM and 7.3 μM at ET_A and ET_B subtypes respectively). Active in vivo.

Technical Data for FR 139317

M. Wt	604.75
Formula	C₃₃H₄₄N₆O₅
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	142375-60-8
PubChem ID	107810
InChi Key	LIOKMIQQPDDTNO-UPRLRBBYSA-N
Smiles	O=C([C@H](CC(C)C)NC(N1CCCCCC1)=O)N[C@@H]([C@@](N[C@H](CC2=NC=CC=C2)C(O)=O)=O)CC(C3=CC=CC=C34)=CN4C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for FR 139317

References are publications that support the biological activity of the product.

Sogabe Pharmacological profile of FR139317, a novel, potent endothelin ET_A receptor antagonist. J.Pharmacol.Exp.Ther. 1993 PMID: 8450448
Palacios Role of endothelin ET_A- and ET_B-receptors in haemodynamic compensation following haemorrhage in anaesthetized rats. Br.J.Pharmacol. 2002 PMID: 11861314
Rubanyi and Polokoff Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol.Rev. 1994 PMID: 7831383
Aramori Subtype selectivity of a novel endothelin antagonist, FR139317, for the two endothelin receptors in transfected Chinese hamster ovary cells. Mol.Pharmacol. 1993 PMID: 8429819

FR 139317

Tocris Bioscience, part of Bio-Techne | Catalog # 1210

Key Product Details

Biological Activity for FR 139317

Technical Data for FR 139317

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for FR 139317

Product Documents for FR 139317

COA

Certificate of Analysis

SDS

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