FR 122047 hydrochloride

Name: FR 122047 hydrochloride
Brand: tocris
SKU: 1507

Catalog # 1507

Citations (6)

Datasheet / COA / SDS

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Key Product Details

Description:	Cyclooxygenase (COX-1) inhibitor
Chemical Name:	1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	459.99

View Full Technical Details for FR 122047 hydrochloride

Biological Activity

FR 122047 hydrochloride is a selective cyclooxygenase-1 (COX-1) inhibitor (IC₅₀ values are 0.028 and 65 μM for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo.

Technical Data

M. Wt	459.99
Formula	C₂₃H₂₅N₃O₃S.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	130717-51-0
PubChem ID	196840
InChi Key	YWMAVHIKOAOSFM-UHFFFAOYSA-N
Smiles	Cl.COC1=CC=C(C=C1)C1=C(N=C(S1)C(=O)N1CCN(C)CC1)C1=CC=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	4.6	10

Preparing Stock Solutions

The following data is based on the product molecular weight 459.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.74 mL	108.70 mL	217.40 mL
0.5 mM	4.35 mL	21.74 mL	43.48 mL
1 mM	2.17 mL	10.87 mL	21.74 mL
5 mM	0.43 mL	2.17 mL	4.35 mL

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References

References are publications that support the biological activity of the product.

Dohi The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur.J.Pharmacol. 1993 PMID: 8276067
Ochi The analgesic effect profile of FR122047, a selective cyclo-oxygenase-1 inhibitor, in chemical nociceptive models. Eur.J.Pharmacol. 2000 PMID: 10720634
Ochi and Goto Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br.J.Pharmacol. 2002 PMID: 11834626
Tanaka Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles. J.Med.Chem. 1994 PMID: 8164261

Citations (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for FR 122047 hydrochloride include:

Tunaru et al. (2016) Arachidonic acid metabolite 19(S)-HETE induces vasorelaxation and platelet inhibition by activating prostacyclin (IP) receptor. PLoS One. 11:e0163633
PMID: 27662627
Tunaru et al. (2016) Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor PLoS One. 11:e0163633
PMID: 27662627
Lu et al. (2013) Aspirin minimized the pro-metastasis effect of sora. and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma. J Biol Chem. 8:e65023
PMID: 23741443
Tunaru et al. (2012) Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. PLoS One. 109:9179
PMID: 22615395
Chia et al. (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol. 11:10
PMID: 21955547
Passafaro et al. (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. J Virol. 8:138
PMID: 22013477
Ray et al. (2004) Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. Proc Natl Acad Sci U S A. 78:12964
PMID: 15542648

There are no citations that match your criteria.

Showing 1 - 6 of 6 citations Showing All

Product Documents

COA

Certificate of Analysis

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FR 122047 hydrochloride

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References

Citations (6)

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