Fostriecin sodium salt

Name: Fostriecin sodium salt
Brand: Tocris Bioscience
SKU: 1840
Rating: 4 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1840

(2)

Citations (8)

COA / SDS

Potent PP2A and PP4 inhibitor

Discontinued Product

1840 has been discontinued. View all Protein Ser/Thr Phosphatase Inhibitors products.

Key Product Details

Description:	Potent PP2A and PP4 inhibitor
Chemical Name:	(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	452.37

View Full Technical Details for Fostriecin sodium salt

Technical Data
Citations / Reviews (2)

Biological Activity for Fostriecin sodium salt

Fostriecin sodium salt is a potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC₅₀ values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC₅₀ = 40 μM) and protein phosphatase type 1 (PP1) (IC₅₀ = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.

Technical Data for Fostriecin sodium salt

M. Wt	452.37
Formula	C₁₉H₂₆O₉PNa
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	87860-39-7
PubChem ID	16759606
InChi Key	XBUIKNRVGYFSHL-IAVQPKKASA-M
Smiles	[Na+].C[C@@](O)(\C=C\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\C=C/C=C\C=C\CO)OP(O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Fostriecin sodium salt

References are publications that support the biological activity of the product.

Walsh Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 1997 PMID: 9373158
Hastie and Cohen Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett. 1998 PMID: 9714542
Tunac Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties. J.Antibiot. 1983 PMID: 6689323

Fostriecin sodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 1840

Key Product Details

Biological Activity for Fostriecin sodium salt

Technical Data for Fostriecin sodium salt

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Fostriecin sodium salt

Product Documents for Fostriecin sodium salt

COA

Certificate of Analysis

SDS

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