Flumazenil is a benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABA_A receptors. Centrally active upon systemic administration in vivo. Also inhibits repressor element-1 silencing transcription factor (REST) by targeting degradation.

Product Specifications

Molecular Weight

303.29

Formula

C₁₅H₁₄FN₃O₃

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester

CAS Number

78755-81-4

PubChem ID

3373

InChI Key

OFBIFZUFASYYRE-UHFFFAOYSA-N

SMILES

CCOC(=O)C1=C2CN(C)C(=O)C3=CC(F)=CC=C3N2C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		25

Preparing Stock Solutions for Flumazenil

The following data is based on the product molecular weight 303.29

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	13.19 mL	65.94 mL	131.89 mL
1.25 mM	2.64 mL	13.19 mL	26.38 mL
2.5 mM	1.32 mL	6.59 mL	13.19 mL
12.5 mM	0.26 mL	1.32 mL	2.64 mL

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Background References

References are publications that support the biological activity of the product.

Dobl New insights into the mechanism of action of hypnotics. J.Psychopharmacol. 1999 PMID: 10667451
Polc Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788. Naunyn Schmiedebergs Arch.Pharmacol. 1981 PMID: 7196507
Atack Regional differences in the inhibition of mouse in vivo [³H]Ro 15-1788 binding reflect selectivity for α1 versus α2 and α3 subunit-containing GABA_A receptors. Neuropsychopharmacology 1999 PMID: 10063485

Flumazenil

Tocris Bioscience, part of Bio-Techne | Catalog # 1328

Key Product Details

Description

Alternative Names

View all GABA-A Receptor Benzodiazepines »

Product Description