Felodipine

Name: Felodipine
Brand: Tocris Bioscience
SKU: 2960
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2960

(1)

COA / SDS

CaV1.x blocker

Discontinued Product

2960 has been discontinued. View all Cav1.x Channel Blockers products.

Key Product Details

Description:	Ca_V1.x blocker
Chemical Name:	4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	384.25

View Full Technical Details for Felodipine

Technical Data
Citations / Reviews (1)

Biological Activity for Felodipine

Felodipine is a L-type Ca²⁺ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Compound Libraries for Felodipine

Felodipine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Felodipine

M. Wt	384.25
Formula	C₁₈H₁₉Cl₂NO₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	72509-76-3
PubChem ID	3333
InChi Key	RZTAMFZIAATZDJ-UHFFFAOYSA-N
Smiles	ClC1=C(Cl)C(C2C(C(OC)=O)=C(C)NC(C)=C2C(OCC)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Felodipine

References are publications that support the biological activity of the product.

Furukawa Selectivities of dihydropyridine derivatives in blocking Ca²⁺ channel subtypes expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 1999 PMID: 10525060
Furukawa Differential blocking action of dihydropyridine Ca²⁺ antagonists on a T-type Ca²⁺ channel (α_1G) expressed in Xenopus oocytes. J.Cardiovasc.Pharmacol. 2005 PMID: 15725949
Ljung Vascular selectivity of felodipine: experimental pharmacology. J.Cardiovasc.Pharmacol. 1990 PMID: 1693715