Exemestane

Name: Exemestane
Brand: Tocris Bioscience
SKU: 3759

Tocris Bioscience, part of Bio-Techne | Catalog # 3759

Citations (10)

COA / SDS

Steroidal aromatase (CYP19) inhibitor

Discontinued Product

3759 has been discontinued. View all Cytochrome P450 Inhibitors products.

Key Product Details

Description:	Steroidal aromatase (CYP19) inhibitor
Alternative Names:	FCE 24304,EXE
Chemical Name:	6-Methyleneandrosta-1,4-diene-3,17-dione
Purity:	≥99% (HPLC)
Molecular Weight:	296.4

View Full Technical Details for Exemestane

Technical Data
Citations

Biological Activity for Exemestane

Exemestane is an irreversible steroidal aromatase inhibitor (IC₅₀ = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Exemestane

Exemestane is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Exemestane

M. Wt	296.4
Formula	C₂₀H₂₄O₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	107868-30-4
PubChem ID	60198
InChi Key	BFYIZQONLCFLEV-DAELLWKTSA-N
Smiles	C[C@@]12C(C(C[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O)=C)=CC(C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Exemestane

References are publications that support the biological activity of the product.

di Salle Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 1992 PMID: 1525055
Wang and Chen Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor. Cancer Res. 2006 PMID: 17079446
Miller Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 2008 PMID: 18695261
Goss The steroidal aromatase inhibitor exeme. prevents bone loss in ovariectomized rats. Bone 2004 PMID: 15003786