ETP 45835 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5183
Mnk1 and Mnk2 inhibitor
Discontinued Product
5183 has been discontinued.
View all Mnk Inhibitors products.
Product Description
ETP 45835 dihydrochloride is a Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.Product Specifications
Molecular Weight
301.21
Formula
C13H16N4.2HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]pyridine dihydrochloride
CAS Number
2136571-30-5
PubChem ID
71755761
InChI Key
ASYCTHXAPLLLSZ-UHFFFAOYSA-N
SMILES
C1(C2=CC(C3=CC=NC=C3)=NN2)CCNCC1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.12 | 100 |
Preparing Stock Solutions
for ETP 45835 dihydrochloride
The following data is based on the product molecular weight 301.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.60 mL | 33.20 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Oyarzabal Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 2010 PMID: 20722422
Product Specific Notices for ETP 45835 dihydrochloride
For research use only
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