ETP 45835 dihydrochloride

Name: ETP 45835 dihydrochloride
Brand: Tocris Bioscience
SKU: 5183

Tocris Bioscience a Bio-Techne Brand

Catalog # 5183

Citations (1)

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Key Product Details

Description:	Mnk1 and Mnk2 inhibitor
Chemical Name:	4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]pyridine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	301.21

View Full Technical Details for ETP 45835 dihydrochloride

Biological Activity for ETP 45835 dihydrochloride

ETP 45835 dihydrochloride is a Mnk2 and Mnk1 inhibitor (IC₅₀ values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.

Technical Data for ETP 45835 dihydrochloride

M. Wt	301.21
Formula	C₁₃H₁₆N₄.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
PubChem ID	71755761
InChi Key	ASYCTHXAPLLLSZ-UHFFFAOYSA-N
Smiles	C1(C2=CC(C3=CC=NC=C3)=NN2)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ETP 45835 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	30.12	100

Preparing Stock Solutions for ETP 45835 dihydrochloride

The following data is based on the product molecular weight 301.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.32 mL	16.60 mL	33.20 mL
5 mM	0.66 mL	3.32 mL	6.64 mL
10 mM	0.33 mL	1.66 mL	3.32 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References for ETP 45835 dihydrochloride

References are publications that support the biological activity of the product.

Oyarzabal Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 2010 PMID: 20722422

Citations for ETP 45835 dihydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for ETP 45835 dihydrochloride include:

Ichiyanagi et al. (2019) Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma. Oncotarget. 10:4053
PMID: 31258849

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