Endomorphin-1

Name: Endomorphin-1
Brand: tocris
SKU: 1055

Catalog # 1055

Citations (3)

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Key Product Details

Description:	Potent and selective μ agonist
Molecular Weight:	610.67

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Biological Activity

Endogenous peptide with an exceptionally high affinity (K_i = 360 pM) and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively).

Technical Data

M. Wt	610.67
Formula	C₃₄H₃₈N₆O₅
Single Letter Sequence	YPWF (Modifications: Phe-3 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	189388-22-5
PubChem ID	5311080
InChi Key	ZEXLJFNSKAHNFH-SYKYGTKKSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble to 0.6mg in water

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References

References are publications that support the biological activity of the product.

Goldberg Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 1998 PMID: 9694962
Harrison Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 1998 PMID: 9622031
Kakizawa Parallel stimulations of in vitro and in situ [³⁵S]GTPγS binding by endomorphin 1 and DAMGO in mouse brains. Peptides 1998 PMID: 9622032
Zadina A potent and selective endogenous agonist for the μ-opiate receptor. Nature 1997 PMID: 9087409

Citations (3)

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Citations are publications that use Bio-Techne products. Selected citations for Endomorphin-1 include:

Hauser et al. (2018) Pharmacogenomics of GPCR Drug Targets. Cell. 172:41
PMID: 29249361
Dortch-Carnes and Russell (2007) Morphine-stimulated nitric oxide release in rabbit aqueous humor. Am J Physiol Endocrinol Metab. 84:185
PMID: 17094965
Garzón et al. (2004) RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Neuropsychopharmacology. 29:1091
PMID: 14997173

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Product Datasheets

COA

Certificate of Analysis

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Endomorphin-1

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Key Product Details

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Biological Activity

Technical Data

Solubility

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Dilution Calculator

Reconstitution Calculator

References

Citations (3)

Product Datasheets

COA

Certificate of Analysis

SDS

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