EMD 66684

Name: EMD 66684
Brand: Tocris Bioscience
SKU: 1849

Catalog # 1849

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Key Product Details

Description:	Potent and selective non-peptide AT₁ antagonist
Chemical Name:	2-Butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl-4-yl]methyl]-5H-imidazo[4,5-c]pyridine-5-acetamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	547.05

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Biological Activity

EMD 66684 is a highly potent and very selective non-peptide angiotensin AT₁ receptor antagonist (IC₅₀ values are 0.7 and > 10000 nM for AT₁ and AT₂ receptors respectively). Potently inhibits angiotensin II-induced contractions in isolated rabbit aorta (IC₅₀ = 0.2 nM) and reduces blood pressure in hypertensive rats.

Compound Libraries

EMD 66684 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	547.05
Formula	C₂₈H₃₀N₈O₂.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	1216884-39-7
PubChem ID	56972165
InChi Key	YMFXGXGDHBXTPY-UHFFFAOYSA-N
Smiles	Cl.CCCCC1=NC2=C(N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NN=NN1)C(=O)N(CC(=O)N(C)C)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.35	50
	ethanol	27.35	50

Preparing Stock Solutions

The following data is based on the product molecular weight 547.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.66 mL	18.28 mL	36.56 mL
2.5 mM	0.73 mL	3.66 mL	7.31 mL
5 mM	0.37 mL	1.83 mL	3.66 mL
25 mM	0.07 mL	0.37 mL	0.73 mL

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References

References are publications that support the biological activity of the product.

Mederski 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT₁ antagonists with improved affinity for the AT₂ receptor. Bioorg.Med.Chem.Lett.
Mederski Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. J.Med.Chem. 1994 PMID: 8201597

Citations for EMD 66684

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