DuP 697

Name: DuP 697
Brand: tocris
SKU: 1430

Catalog # 1430

Citations (5)

Datasheet / COA / SDS

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Key Product Details

Description:	Cyclooxygenase-2 (COX-2) inhibitor
Chemical Name:	5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene
Purity:	≥99% (HPLC)
Molecular Weight:	411.3

View Full Technical Details for DuP 697

Biological Activity

DuP 697 is a potent and selective inhibitor of cyclooxygenase-2 (IC₅₀ values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo. Orally active.

Compound Libraries

DuP 697 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	411.3
Formula	C₁₇H₁₂BrFO₂S₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	88149-94-4
PubChem ID	3177
InChi Key	AJFTZWGGHJXZOB-UHFFFAOYSA-N
Smiles	CS(=O)(=O)C1=CC=C(C=C1)C1=C(SC(Br)=C1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.13	100

Preparing Stock Solutions

The following data is based on the product molecular weight 411.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.16 mL	24.31 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References

References are publications that support the biological activity of the product.

Gans Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J.Pharmacol.Exp.Ther. 1990 PMID: 2366180
Gierse Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 1995 PMID: 7832763
Rossoni Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit. Br.J.Pharmacol. 2002 PMID: 11906968

Citations (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for DuP 697 include:

Gonnermann et al. (2015) Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity. Oncoimmunology. 4:e988460
PMID: 25949900
Alsaqati et al. (2013) Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries. Purinergic Signal. 10:241
PMID: 24310605
Passafaro et al. (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Neuroscience. 8:138
PMID: 22013477
Choi et al. (2010) Roles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor. Korean J Pain. 23:236
PMID: 21217886
Wong et al. (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res. 104:228
PMID: 19096033

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Showing 1 - 5 of 5 citations Showing All

Product Documents

COA

Certificate of Analysis

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DuP 697

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Key Product Details

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Biological Activity

Compound Libraries

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (5)

Product Documents

COA

Certificate of Analysis

SDS

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