DuP 697
Tocris Bioscience, part of Bio-Techne | Catalog # 1430
Cyclooxygenase-2 (COX-2) inhibitor
Discontinued Product
1430 has been discontinued.
View all Cyclooxygenase Inhibitors products.
Key Product Details
Description
Cyclooxygenase-2 (COX-2) inhibitor
Product Description
DuP 697 is a potent and selective inhibitor of cyclooxygenase-2 (IC50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo. Orally active.Product Specifications
Molecular Weight
411.30
Formula
C17H12BrFO2S2
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene
CAS Number
88149-94-4
PubChem ID
3177
InChI Key
AJFTZWGGHJXZOB-UHFFFAOYSA-N
SMILES
CS(=O)(=O)C1=CC=C(C=C1)C1=C(SC(Br)=C1)C1=CC=C(F)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.13 | 100 |
Preparing Stock Solutions
for DuP 697
The following data is based on the product molecular weight 411.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.43 mL | 12.16 mL | 24.31 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.43 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gierse Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 1995 PMID: 7832763
- Rossoni Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit. Br.J.Pharmacol. 2002 PMID: 11906968
- Gans Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J.Pharmacol.Exp.Ther. 1990 PMID: 2366180
Product Specific Notices for DuP 697
For research use only
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