Domoic acid

Name: Domoic acid
Brand: tocris
SKU: 0269

Catalog # 0269

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	Potent and selective kainate agonist
Chemical Name:	(2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineacetic acid
Purity:	≥95% (HPLC)
Molecular Weight:	311.33

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Technical Data
Citations (1) / Reviews

Biological Activity

Kainate receptor agonist. More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.

Technical Data

M. Wt	311.33
Formula	C₁₅H₂₁NO₆
Storage	Desiccate at -20°C
Purity	≥95% (HPLC)
CAS Number	14277-97-5
PubChem ID	5282253
InChi Key	VZFRNCSOCOPNDB-AOKDLOFSSA-N
Smiles	[H][C@](C)([C@](O)=O)/C=C/C=[C@@](C)\[C@H]1CN[C@H]([C@@](O)=O)[C@H]1CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	15.57	50

Preparing Stock Solutions

The following data is based on the product molecular weight 311.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.42 mL	32.12 mL	64.24 mL
2.5 mM	1.28 mL	6.42 mL	12.85 mL
5 mM	0.64 mL	3.21 mL	6.42 mL
25 mM	0.13 mL	0.64 mL	1.28 mL

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References

References are publications that support the biological activity of the product.

Agrawal and Evans The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 1986 PMID: 3513882
Debonnel Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus. Can.J.Physiol.Pharmacol. 1989 PMID: 2540893
Watkins Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Excitatory Amino Acids and Synaptic Plasticity. Ed
Hampson and Manalo The activation of glutamate receptors by kainic acid and domoic acid. Nat.Toxins 1998 PMID: 10223631

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Domoic acid include:

Rojas et al. (2013) Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol. 83:106
PMID: 23066089

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Product Datasheets

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Certificate of Analysis

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Domoic acid

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References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

SDS

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