(±)-Anatoxin A fumarate

Name: (±)-Anatoxin A fumarate
Brand: tocris
SKU: 0789

Catalog # 0789

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	nAChR agonist
Chemical Name:	(±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate
Purity:	≥96% (HPLC)

View Full Technical Details for (±)-Anatoxin A fumarate

Biological Activity

A potent nicotinic agonist (K_i values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). Stimulates [³H]-dopamine release from rat striatal synaptosomes (EC₅₀ = 136 nM).

Technical Data

M. Wt	281.31
Formula	C₁₀H₁₅NO.C₄H₄O₄
Storage	Desiccate at +4°C
Purity	≥96% (HPLC)
CAS Number	1219922-30-1
PubChem ID	45073416
InChi Key	ZJSIFVODFDHYJU-WLHGVMLRSA-N
Smiles	O=C(C)C1=CCCC2CCC1N2.O=C(O)/C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	14.07	50

Preparing Stock Solutions

The following data is based on the product molecular weight 281.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.11 mL	35.55 mL	71.10 mL
2.5 mM	1.42 mL	7.11 mL	14.22 mL
5 mM	0.71 mL	3.55 mL	7.11 mL
25 mM	0.14 mL	0.71 mL	1.42 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Gordon Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A. J.Pharmacol.Exp.Ther. 1992 PMID: 1469655
Sharples UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 2000 PMID: 10751429
Stolerman Behavioural effects of anatoxin, a potent nicotinic agonist in rats. Neuropharmacology 1992 PMID: 1630597
Thomas (+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J.Neurochem. 1993 PMID: 8492133

Showing 1-1 of 1 citation

Citations (1)

Citations are publications that use Bio-techne products. Selected citations for (±)-Anatoxin A fumarate include:

Gagnon and Pick (2012) Effect of nitrogen on cellular production and release of the neurotoxin anatoxin-a in a nitrogen-fixing cyanobacterium. Front Microbiol. 3:211
PMID: 22701451

(±)-Anatoxin A fumarate

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Solubility

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Reconstitution Calculator

References

Citations (1)

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