Dimaprit dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0506
Standard H2 selective agonist
Discontinued Product
0506 has been discontinued.
View all Histamine H2 Receptor Agonists products.
Key Product Details
Description
Standard H2 selective agonist
Product Description
Dimaprit dihydrochloride is a selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).Product Specifications
Molecular Weight
234.19
Formula
C6H15N3S.2HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
S-(3-Dimethylaminopropyl)isothiourea dihydrochloride
CAS Number
23256-33-9
PubChem ID
90045
InChI Key
DFWCPLGXFMSUCW-UHFFFAOYSA-N
SMILES
CN(C)CCCSC(N)=N.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.42 | 100 |
Preparing Stock Solutions
for Dimaprit dihydrochloride
The following data is based on the product molecular weight 234.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.27 mL | 21.35 mL | 42.70 mL |
| 5 mM | 0.85 mL | 4.27 mL | 8.54 mL |
| 10 mM | 0.43 mL | 2.14 mL | 4.27 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.85 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Parsons Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. Agents Actions 1977 PMID: 871093
- Farzin and Attarzadeh Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 2000 PMID: 10980276
- Paquay Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 1999 PMID: 10385230
- Durant Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations. Agents Actions 1977 PMID: 860674
Product Specific Notices for Dimaprit dihydrochloride
For research use only
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