Dimaprit dihydrochloride

Name: Dimaprit dihydrochloride
Brand: Tocris Bioscience
SKU: 0506

Tocris Bioscience a Bio-Techne Brand

Catalog # 0506

Citations (3)

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Key Product Details

Description:	Standard H₂ selective agonist
Chemical Name:	S-(3-Dimethylaminopropyl)isothiourea dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	234.19

View Full Technical Details for Dimaprit dihydrochloride

Biological Activity for Dimaprit dihydrochloride

Dimaprit dihydrochloride is a selective H₂ agonist with central effects upon systemic administration. Also inhibits nNOS (IC₅₀ = 49 μM).

Technical Data for Dimaprit dihydrochloride

M. Wt	234.19
Formula	C₆H₁₅N₃S.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	23256-33-9
PubChem ID	90045
InChi Key	DFWCPLGXFMSUCW-UHFFFAOYSA-N
Smiles	CN(C)CCCSC(N)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dimaprit dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	23.42	100

Preparing Stock Solutions for Dimaprit dihydrochloride

The following data is based on the product molecular weight 234.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.27 mL	21.35 mL	42.70 mL
5 mM	0.85 mL	4.27 mL	8.54 mL
10 mM	0.43 mL	2.14 mL	4.27 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

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References for Dimaprit dihydrochloride

References are publications that support the biological activity of the product.

Farzin and Attarzadeh Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 2000 PMID: 10980276
Paquay Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 1999 PMID: 10385230
Durant Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H₂-receptor agonist. Part 2. Structure activity considerations. Agents Actions 1977 PMID: 860674
Parsons Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H₂-receptor agonist. Part 1. Pharmacology. Agents Actions 1977 PMID: 871093

Citations for Dimaprit dihydrochloride (3)

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Citations are publications that use Bio-Techne products. Selected citations for Dimaprit dihydrochloride include:

Wang et al. (2014) Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line. J Immunol. 3:1126
PMID: 25045085
Swartzendruber et al. (2012) Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses. Stem Cells Transl Med. 188:536
PMID: 22156496
Fei et al. (2009) Stimulation of mucosal secretion by lubipro. (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol. 296:G823
PMID: 19179625

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Product Documents for Dimaprit dihydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.